Since I have them both I'll give you my few thoughts of them:
Originally Posted by: michelvr 
Just to clarify; My selection is between either the Marklin Central Station 60215 or the ESU ECoS 50200.
What I'm asking is I'm used to changing CV's and setting up consisting with more than two or three locomotives. My layout room is large 45' X 12'. I have already used DCC for my layout and now I am starting over with Marklin. I am starting over from scratch, which means I do not presently own a digital system. I have no experience with Marklin and have not used either of the systems that I have selected.
The $64,000 questions are: Can Marklin Central Station 60215 or the ESU ECoS 50200 do the following;
Train detecting
Do you mean occupancy detection? Both of them can handle that!
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Consisting
Interface with computer
Computer control with software i.e.: TrainController
Both will do this nicely
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Program decoder and change sound files
For changing sounds ESU has the LokProgrammer, whilst the CS2 at least will be able to do this. Other decoder programming is possible on both units. If the EcoS will be able to manage sound files - can't tell.
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AND most importantly short protection on the layout. Let me explain:
Separate the layout utilizing boosters and electrical short management to prevent total layout shutdown when shorts occur in any given section. If a short happens in one section, only that section will shut down, the rest of my layout will keep working. The reason I want this is because I know from experience that electrical shorts happen all the time and with the boosters seperating the layout into sections the setup will work properly. With electrical short management I will have no worries with frying a locomotive or welding wheel sets to the tracks and with all of the boosters linked to the digital command system/station they will continue to receive the DCC signal and output it to their own section of track leaving the other trains running.
Michel
On the booster issue I know the ECoSBoosters can shut down their power districts only - which I think the CS2 boosters also can (haven't got that confirmed though).
There are som other issues that for me spoke for the ECoS, for instance the new implementation of (non-computerized) routes, the possibility to "lock-out" accessories (with computer control), as well as the possibility to run mfx-locos with "only" 28 speedsteps. Also the availability of RailCom+ gives an extra credit for the ECoS as do the more frequent updates.
Drawback on ECoS is the mfx-registration which takes much longer time - although the CS2 internally implements acceleration- and braking delay (which every now and then compromises the settings of the decoder - if not properly programmed) thus not initially reading all the decoder values.
I still keep the CS2 though - as a reserve as there is no way to wire for subsequent use of them both, maybe there will be a 2:nd layout utilizing the CS2 someday...